Dr. Fan Xiaohu is a well-known expert in the field of Applied Immunology and gene therapy. In 2004, he made a major breakthrough in the basic research of the mechanism of children's blood group incompatibility with heart transplantation. In his original paper published by Nature Medicine, he clarified the mechanism of immune tolerance in the process of children's heart transplantation and demonstrated that infant patients need not consider A before transplantation. BO blood group matched. This achievement breaks the limitation of homogenous organ transplantation and greatly improves the chances of organ transplantation for children with diseases. Returning to China in 2014 and joining Kingsley Group, Kingsley subsidiary Nanjing Legendary Biology was founded in early 2015. Excellent R&D team was established and advanced CAR-T technology platform was independently developed. LCAR-B38M, the first product for the treatment of relapsed and refractory multiple myeloma, achieved international leading results. Since its use in clinical trials in 2016, 74 people have been treated, with a complete response rate of 75%. This product has won a strategic partnership agreement between Johnson & Johnson and Legend to develop the global market for this product. On March 8, 2018, LCAR-B38M products were awarded the first clinical trial approval of CAR-T cell drugs in China, which became an important milestone in the history of cell therapy drugs in China. On May 30, 2018, LCAR-B38M products were also approved by the US FDA for phase Ib/II clinical trials. In 2019, he was eligible for the EU EMA Priority Drug Review. At present, Legendary Biology has the world's largest cell drug research and development team, developed a large number of new CAR-T cancer treatment products and a number of innovative intellectual property platform technology.
In the mid-1990s, Dr. Lai Shoupeng carried out postdoctoral research on cancer immunotherapy in Steven Rosenburg Laboratory, Director of Surgery, National Cancer Institute of the United States. After entering the biomedical industry, he has been engaged in research and development of new biological drugs for more than 20 years. He has accumulated rich experience in biopharmaceutical technology development, GMP production and project management. In 2014, Nanjing leadsbiolabs Co., Ltd. was co-founded, focusing on the development of new anti-cancer drugs for immunotherapy.